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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: Cancer Res. 2010 Dec 15;70(24):10464–10473. doi: 10.1158/0008-5472.CAN-10-0732

Figure 5. NF-κB promotes breast tumor stem cell marker expression and mammosphere production.

Figure 5

A, Analysis of breast cancer stem cell marker CD44 in mammary tumors of PISA mice (N≥3) with or without IκBαSR induced by Ponasterone A. B, Mammosphere assays (N≥4) were conducted of breast cancer cell lines derived from 3 separate PISA/ErbB2 cell lines (left diagram) and in Met-1 cells (right diagram), and quantitation was conducted after 10 days. Treatment was with the IKKα inhibitor (Bay11-7082, 10μM). C, D, Stem cell surface markers (CD24−/low/CD44+/+) of breast cancer cell line PISA/ErbB2 (C) or Met-1 (D). Cells were transduced with IκBαSR or control vector (N≥3).