TABLE 7. Effects of TRH on sleep and hypothermia produced by secobarbital, amobarbital, phenobarbital and thiopental^a.

Barbiturate	Dose	Sleeping Time		Rectal Temperatureb
		Control	TRH	Control	TRH
	mg/kg	min ± S.E.M.		°C ± S.E.M.
Secobarbital Na	50	91.1 ± 9.54	39.9 ± 4.56c	32.5 ± 0.24	36.0 ± 0.28c
Amobarbital Na	110	73.8 ± 5.55	48.7 ± 5.23c	33.8 ± 0.02	35.9 ± 0.20c
Phenobarbital Na	150	96.8 ± 5.34	8.4 ± 4.96c	34.4 ± 0.22	35.6 ± 0.38d
Thiopental Na	55	70.1 ± 16.6	33.9 ± 3.93c	34.7 ± 0.65	37.1 ± 0.40d
Pentobarbital Na	50	59.3 ± 4 10	22.4 ± 2.93c	33.8 ± 1.22	36.7 ± 0.40e

^aMice were treated with TRH (5 mg/kg i.p.) 1 minute before the various barbiturate derivatives (i.p.) except for the phenobarbital group which received the TRH 30 minutes after the phenobarbital. Values represent the mean ± S.E.M. of 12 animals for all drugs.

^bRectal temperature was measured 20 minutes after the barbiturate

^cP < .001 when compared with control.

^dP < .025 when compared with control

^eP < .05 when compared with control