. Author manuscript; available in PMC: 2010 Dec 28.

Published in final edited form as: J Pharmacol Exp Ther. 1975 Apr;193(1):11–22.

TABLE 8. Effect of TRH on locomotor activity and temperature after treatment with reserpine, chloral hydrate, chlorpromazine, diazepam, and phenobarbital.

Treatment^a	Dose	Motor Activity	Rectal Temperature

	mg/kg	Counts/hr ± S.E.M	°C ± S.E.M.
Reserpine	2.5	48 ± 27	33.3 ± 0.26
Reserpine + TRH	2.5 + 30	1610 ± 290^b	38.3 ± 0.56^b
Chloral hydrate	360.0	33 ± 8	31.4 ± 0.85
Chloral hydrate + TRH	360.0 + 30	608 ± 74^b	33.1 ± 0.33
Chlorpromazine	6.0	91 ± 29	34.0 ± 0.56
Chlorpromazine + TRH	6.0 + 30	882 ± 96^b	38.4 ± 0.26^b
Diazepam	12.5	80 ± 16	35.2 ± 0.37
Diazepam + TRH	12.5 + 30	1131 ±479^b	37.3 ± 0.42^c
Phenobarbital	95.0	294 ± 143	35.9 ± 0.25
Phenobarbital + TRH	95.0 + 30	2634 ± 284^b	38.0 ± 0.22^b

All animals received 30 mg/kg of TRH after the various drugs. Details are described in “Methods.” Values in animals that did not receive TRH indicate base-line data after animals were injected with saline rather than TRH. Temperature was recorded in a separate group of mice 30 minutes after animals received TRH. Temperature in untreated control mice was 37.8 ± 0.19°C and with TRH was 38.5 ± 0.25°C (P < .01). Each value represents the mean ± S.E.M. of at least 10 mice.

P < .001 when compared with control.

P < .005 when compared with control.