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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: Immunity. 2010 Dec 14;33(6):967–978. doi: 10.1016/j.immuni.2010.11.025

Figure 3. DCs other than LCs contribute to dermatitis.

Figure 3

(A) Percentage of female control (n = 20) and CD11c:DTA (n = 12) mice with dermatitis at 16 wk of age.

(B) Epidermal sheets from control and CD11c:DTA mice were stained for I-A/I-E (mouse MHC class II) to identify LCs (red). The images in the middle and on the right side represent 2 visual fields from the same sample to better illustrate that, rarely, small Langerhans cell clusters were detectable in CD11c:DTA mice. Data are representative of epidermal sheets from 3 mice of each type. Scale bar = 50 μm.

(C) Percentage of female control (n = 19) and Langerhans-DTA (n = 16) mice with dermatitis until death. The mean survival of Langerin-DTA mice was 145.2 days and of control mice 141.7 days.

D) Epidermal sheets from control and Langerin-DTA mice stained as in (B). Data are representative of epidermal sheets from 3 mice of each type. Scale bar = 50 μm. Statistics were calculated by Fisher’s exact test. **p < 0.01.