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. 2011 Jan 5;100(1):42–51. doi: 10.1016/j.bpj.2010.10.046

Figure 1.

Figure 1

Effect of HC on 5-HT3ARs evaluated at the single-channel level. (a) Left: Channels activated at 1 μM of 5-HT in the absence or presence of increasing HC concentrations in the pipette solution. A single cluster is shown at two different time resolutions for each condition. Right: Representative open-, closed-, and cluster-duration histograms obtained from the entire recording at each condition. The arrow shows the 8-ms closed-time component associated with the block. (b) Continuous single-channel traces of control and 400-μM-HC-treated channels activated by 1 μM 5-HT. Membrane potential, −70 mV; filter, 10 kHz.