Figure 2.

HC increases the frequency of the subconductance state. (a) A typical cluster of 5-HT₃AR activated by 1 μM 5-HT in the absence (upper) and presence of 400 μM HC (lower), with a segment shown at higher resolution. Membrane potential, −70 mV; filter, 10 kHz. (b) Typical amplitude histograms for 0, 100, 200, and 400 μM HC. To determine mean amplitudes, histograms were constructed only with events whose durations were >90 μs. (c and d) Mean amplitudes (c) and relative areas (d) resulting from the histograms in b for the high- (black) and low-conductance events (gray) (mean ± SD for at least n = 3 for each condition).