Table 2.
SNCA Haplotype Analysis
| #a | Haplotypeb | Frequency (cases) |
Frequency (controls) |
OR (95% CI) | p-value | ||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 259 or 261 | T | A | T | T | 0.483 | 0.554 | Reference | |
| 2 | 259 or 261 | C | G | C | C | 0.273 | 0.223 | 1.43 (1.29–1.59) | 4.1 × 10−11 |
| 3 | 263 | T | G | T | C | 0.070 | 0.053 | 1.49 (1.20–1.86) | 3.7 × 10−4 |
| 4 | 259 or 261 | T | G | T | T | 0.042 | 0.050 | 0.93 (0.73–1.20) | 0.600 |
| 5 | 259 or 261 | T | A | C | C | 0.048 | 0.046 | 1.24 (0.99–1.55) | 0.055 |
| 6 | 259 or 261 | C | G | T | T | 0.028 | 0.029 | 1.16 (0.88–1.53) | 0.292 |
| 7 | 259 or 261 | T | G | T | C | 0.023 | 0.020 | 1.30 (0.96–1.76) | 0.094 |
Data presented are for the combined sample in an additive model adjusted for age and sex
a
Haplotypes are numbered in order of descending frequency in controls
b
Haplotypes comprised of REP1, rs2619364, rs2737029, rs2572324, and rs356219 (in that order). REP1 alleles 259 and 261 were grouped together. Haplotypes with an estimated frequency < 0.01 in cases and controls were excluded.
OR = odds ratio; CI = confidence interval