Table 3.

Stratified Analyses for rs356219

	Na	MAF	OR (95% CI)	p-value
Total PD	1942	0.44	1.41 (1.28–1.55)	1.6 × 10−12
Familial PDb	431	0.44	1.40 (1.20–1.62)	1.5 × 10−5
Sporadic PDc	1511	0.44	1.40 (1.27–1.54)	1.2 × 10−11
Total Controls	2060	0.36	-	-
Early-onset PDd	489	0.44	1.37 (1.14–1.63)	5.2 × 10−4
Younger Controlse	591	0.37	-	-
Late-onset PDf	1453	0.44	1.41 (1.27–1.56)	2.2 × 10−10
Older Controlsg	1469	0.36	-	-

Data presented are for the combined sample in an additive, unadjusted model

^aFourteen cases and 52 controls failed genotyping for rs356219

^bPatients with at least one first or second-degree relative with PD

^cPatients with no first or second-degree relatives with PD

^dAge at onset ≤ 50 years

^eRandom sample of controls selected in proportion to the age at enrollment distribution of early-onset cases

^fAge at onset > 50 years

^gTotal controls - younger controls

MAF = minor allele frequency; OR = odds ratio; CI = confidence interval; PD = Parkinson's disease