Fig. 6.

Intercellular adhesion molecule-1 (ICAM-1) reversed suppression of osteoclast differentiation of mouse bone marrow cells by interleukin (IL)-6. Mouse bone marrow cells were stimulated by soluble receptor activator of nuclear factor-κB ligand (sRANKL) (50 ng/ml) and M-CSF (30 ng/ml) in the presence of IL-6 (100 ng/ml) and sICAM-1 (1000 ng/ml) for 3 days (a), and the number of multi-nuclear tartrate-resistant acid phosphatase (TRAP)-positive cells containing more than three nuclei was scored (b). Statistical significances were analysed by t-test (*P < 0·05).