Skip to main content
. 2010 Dec 28;5(12):e14434. doi: 10.1371/journal.pone.0014434

Figure 4. Isometric force contractions measurement in LARGE transgenic and the wild-type mouse muscle.

Figure 4

Maximum isometric forces of tibialis anterior (TA) muscles from 2 and 8 month old LARGE transgenic mice (LV5, line 126) and their age-matched wild-type littermates (WT) were recorded in vivo and weighed following physiological assessments. (A) The weights of TA muscles from 2 month (2 mo) and 8 month (8 mo) old LARGE trangenics (LV5) were not significantly different from the TA muscles of the age-matched wild-type controls. (B and C) Both the maximum absolute forces (B) and the specific forces (C) of TA muscles from LARGE transgenics (LV5) at both 2 and 8 months of age were not significantly different from their age-matched wild-type controls. Number of animals examined: 2 months, LV5 n = 6; WT n = 4; 8 months, LV5 n = 4, WT n = 4. All values presented are mean and standard error of the mean (S.E.M).