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. 2010 Dec 28;5(12):e15525. doi: 10.1371/journal.pone.0015525

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Valeri et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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a) Analysis of chromosomal aberrations in human cord blood CD34⁺ cells transduced with MIN-R1 or MIN-210 and re-infected with Neo^r or BRCA1/neo^r RVs. Data corresponding to samples unexposed or exposed to DEB (0.1 µg/ml) are shown. b) Analysis of cells with multiple chromosomal aberrations in samples corresponding to panel a. Multiaberrant cells consisted on cells with two or more chromosomal breaks per cell. Data show the percentage of cells with aberrant and multiaberrant chromosomes, as deduced from the scoring of at least 50 metaphases. Pooled data obtained from two experiments with MIN RVs and one with MIG RVs are represented. c) Representative microphotograph of a multiaberrant metaphase BCR/ABL CD34⁺ Neo^r in the presence of DEB. Chromatid-type aberrations are shown with arrows.