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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Trends Endocrinol Metab. 2011 Jan;22(1):1–8. doi: 10.1016/j.tem.2010.09.002

Figure 2.

Figure 2

FAS generates an endogenous ligand for PPARα in liver. FAS, a homodimer, synthesizes palmitate, which is converted to a CoA species that is incorporated into diacylglycerol (DAG). CDP-choline is generated by the sequential actions of CK (choline kinase) and CCT (CTP:phosphocholine cytidylyltransferase), enzymes in the Kennedy pathway of phosphatidylcholine synthesis. DAG and CDP-choline are converted by the ER protein choline-ethanolamine phosphotransferase-1 (CEPT1) to 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine. This phosphatidylcholine species binds to PPARα, which forms a heterodimer with RXR to activate gene expression.