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. Author manuscript; available in PMC: 2012 Feb 4.

Published in final edited form as: Toxicology. 2010 Nov 21;280(1-2):10–17. doi: 10.1016/j.tox.2010.11.003

Liver damage by TCDD and BDL is exaggerated in Cyp1a1/1a2(−/−) double-knockout mice. (A) Body weight changes and liver weight. (B) Plasma bile acids, bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γ-GT), and alkaline phosphatase (ALP). (C) Hematoxylin and eosin staining (H&E) of liver sections (x10 magnification). (D) Plasma TNF protein concentrations. Cyp1a1/1a2(−/−) mice (n = 4 per group) were administered corn oil alone or TCDD (15 μg/kg) via gavage on “Day −5” and subjected to sham operation or BDL on “Day 0”. Liver and blood were collected on “Day +3” by the same method as shown in Figure 1. Values represent the means ± S.D. *P < 0.05; **P < 0.01; ***P < 0.001.

Liver damage by TCDD and BDL is exaggerated in Cyp1a1/1a2(−/−) double-knockout mice. (A) Body weight changes and liver weight. (B) Plasma bile acids, bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γ-GT), and alkaline phosphatase (ALP). (C) Hematoxylin and eosin staining (H&E) of liver sections (x10 magnification). (D) Plasma TNF protein concentrations. Cyp1a1/1a2(−/−) mice (n = 4 per group) were administered corn oil alone or TCDD (15 μg/kg) via gavage on “Day −5” and subjected to sham operation or BDL on “Day 0”. Liver and blood were collected on “Day +3” by the same method as shown in Figure 1. Values represent the means ± S.D. *P < 0.05; **P < 0.01; ***P < 0.001.