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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Trends Endocrinol Metab. 2010 Nov 5;22(1):24–33. doi: 10.1016/j.tem.2010.10.002

Figure 3. Metabolic effects of AR activation in males.

Figure 3

Physiological activation of AR in the central nervous system (CNS) suppresses food intake, increases energy expenditure and decreases body weight. In addition, physiological activation of AR improves peripheral energy and glucose homeostasis by 1) preventing liver steatosis 2) enhancing skeletal muscle insulin sensitivity by increasing PGC1α expression, mitochondrial biogenesis and skeletal muscle oxidative fibers, thus increasing lipid oxidation, 3) decreasing WAT lipogenesis and visceral WAT mass. AR activation also decreases WAT adiponectin and leptin production.