Table I.

Individual Plasma Concentration Profiles of IB Administered in a Form of Non-nonconjugated Substance and in a Form of the Conjugate (Ibuprofen–OHB) as an Oily Solution and o/w Emulsion.

Animal No	Time (h)							AUC0-t (μg/ml·h)
	1	3	6	12	24	36	48
Ibuprofen–OHB oily solution (40 mg IB/kg)
1	1.24	0.58	0.45	0.23	0.71r	0.00	0.00
2	1.10	1.17	0.61	0.18a	0.25	0.00	0.00
3	0.82	0.55	0.46	0.15a	0.11a	0.00	0.00
4	0.87	0.79	0.60	0.67	0.29	0.00	0.00
5	1,68	1.61	1.00	0.28	0.20	0.36	0.25
6	1.86	1.38	0.60	0.15a	0.08a	0.00	0.02a
Mean ± SD	1.26 ± 0.42	1.01 ± 0.44	0.62 ± 0.20	0.28 ± 0.20	0.19 ± 0.09	0.06 ± 0.14	0.04 ± 0.1	13.2 ± 6.7
Ibuprofen-OHB emulsion (40 mg IB/kg)
7	0.28r	0.16r	0.20r	0.18a	0.03a	0.00	0.09a
8	0.91	0.97	0.75	0.31	0.03a	0.00	0.00
9	0.56	0.32	0.30	0.19a	0.04a	0.00	0.00
10	1.19	0.72	0.41	0.19a	0.02a	0.00	0.00
11	0.88	0.38	0.34	0.18a	0.06a	0.00	0.03a
12	1.58	1.33	0.63	0.13a	0.03a	0.00	0.00
Mean ± SD	1.02 ± 0.38	0.74 ± 0.42	0.49 ± 0.19	0.20 ± 0.06	0.04 ± 0.01	0.00	0.02 ± 0.04	7.9 ± 2.2
IB oily solution (25 mg IB/kg)
13	37.36	2.07	0.01a	0.00	0.01a	Not analysed
14	25,28	0.90	0.14a	0.10a	0.00
15	54,74	0.72	0.08a	0.00	0.00
16	10.01	0.04a	0.00	0.00	0.00
17	19.47	0.06a	0.00	0.00	0.00
18	38.41	0.33	0.00	0.00	0.03a
Mean ± SD	30.88 ± 15.91	0.69 ± 0.76	0.04 ± 0.06	0.02 ± 0.04	0.01 ± 0.01			48.4 ± 25.1

^aValues below quantification limit

^rData rejected