Table II.
Physicochemical Properties of Hydrogels Loaded with Diclofenac Sodium/Chitosan Microspheres
| Hydrogels formulae | pH | Gel strength (time in sec) | Viscosity (cps) | Farrow’s constant (n) | Area of hysteresis loop (dyne/s cm2) | Flow behavior |
|---|---|---|---|---|---|---|
| 5% w/v HPMC | 6.5 ± 0.3 | 40.8 ± 2.3 | 93528 ± 235 | 1.12 | 2818.5 | Psuedoplastic with thixotropy |
| 6% w/v HPMC | 6.7 ± 0.05 | 45.6 ± 0.8 | 98242 ± 178 | 1.4 | 3298 | |
| 7%w/v HPMC | 6.8 ± 0. | 48 ± 0.6 | 113768 ± 67 | 1.19 | 3383.95 | |
| 1% w/v Carbopol | 7.4 ± 0. | 82.17 ± 1.2 | 100832 ± 548 | 1.12 | 3154.5 |
Mean values±SD, n = 3