Table III.
Kinetics Parameters of Hydrogel Formulations Loaded with DFS-CS Microspheres and Pure Drug
| Gel Formulae | Zero-order | First-order | Higuchi-model | Korsemeyer-model | ||
|---|---|---|---|---|---|---|
| r 2 | K (% h−1) | r 2 | r 2 | r 2 | n | |
| 5% HPMC+DFS-CS Microspheres | 0.9967 | 6.50 | 0.9879 | 0.9704 | 0.9957 | 0.971 |
| 6% HPMC+DFS-CS Microspheres | 0.9921 | 5.97 | 0.9906 | 0.7622 | 0.992 | 1.077 |
| 7% HPMC+DFS-CS Microspheres | 0.9557 | 5.20 | 0.9593 | 0.926 | 0.979 | 1.11 |
| 1% Carbopol+DFS-CS Microspheres | 0.9911 | 6.10 | 0.9866 | 0.9713 | 0.993 | 1.069 |
| 7% HPMC+drug powder | 0.9713 | 34.84 | – | 0.858 | 0.9927 | 0.905 |
r 2 coefficient of determination, K rate constant according to zero-order analysis, n diffusional exponent Krosemeyer model indicative of the mechanism of drug release
aAnalyzed by the regression coefficient method