Table IV.

Stability of Optimized Organogel Formulation (Organogel with Pluronic)

Time (days)	Temperature	Surface characteristics	Drug content	Viscosity (poise)	pH	Spreadability (gcm/s, mean ± SD, n = 3)
0	RT	–	95.81 ± 1.32	8,959	6.48 ±0.5	18.21 ± 0.53
15	4°C	–	95.66 ± 0.52	9,263	6.96 ± 0.3	18.11 ± 0.35
30	4°C	–	95.52 ± 0.25	8,751	7.10 ± 0.4	19.50 ± 0.65
45	4°C	–	95.45 ± 1.12	9,026	6.87 ± 0.52	17.92 ± 0.69
60	4°C	+	93.58 ± 0.4	9,172	6.95 ± 0.2	17.70 ± 0.5
15	RT	–	95.75 ± 1.86	7,741	7.10 ± 0.2	18.06 ± 0.65
30	RT	–	95.43 ± 0.86	7,652	6.77 ± 0.4	18.11 ± 0.42
45	RT	+	94.84 ± 1.87	7,800	6.52 ± 0.3	18.66 ± 1.2
60	RT	+	93.42 ± 1.19	7,720	7.21 ± 0.6	17.97 ± 0.82
15	60°C	+	94.45 ± 0.38	9,041	7.51 ± 0.1	17.97 ± 0.78
30	60°C	+	93.82 ± 0.63	7,660	6.91 ± 0.3	18.65 ± 0.71
45	60°C	++	92.51 ± 0.24	8,972	6.85 ± 0.5	17.35 ± 1.67
60	60°C	++	91.85 ± 1.54	9,010	6.71 ± 0.3	15.70 ± 0.69

– no change, + slight change, ++ considerable change

SD standard deviation