Table 1. Genotype and allele distributions and P-values in controls, bipolar, schizophrenia and unipolar disorder cases for the CACNA1C polymorphism rs1006737.
| Genotype counts/frequency | Allele counts/frequency | |||||||
|---|---|---|---|---|---|---|---|---|
| n | AA | AG | GG | Trend P-value | A | G | OR (95% CI) | |
| New controls | 1019 | 112 (11.0) | 449 (44.1) | 458 (44.9) | 673 (33.0) | 1365 (67.0) | ||
| UP cases | 1165 | 155 (13.3) | 535 (45.9) | 475 (40.8) | 0.013 | 845 (36.3) | 1485 (63.7) | 1.15 (1.02–1.31) |
| Controls (WTCCC) | 2636 | 336 (11.4) | 1233 (42.0) | 1367 (46.6) | 1905 (32.4) | 3967 (67.6) | ||
| SZ cases | 479 | 66 (13.8) | 208 (43.4) | 205 (42.8) | 0.034 | 340 (35.5) | 618 (64.5) | 1.15 (0.99–1.32) |
| WTCCC expanded reference | 11361 | 1252 (11.0) | 4949 (43.6) | 5160 (45.4) | 7453 (32.8) | 15269 (67.2) | ||
| UP cases | 1165 | 155 (13.3) | 535 (45.9) | 475 (40.8) | 3.9 × 10−4 | 845 (36.3) | 1485 (63.7) | 1.17 (1.07–1.27) |
| SZ cases | 479 | 66 (13.8) | 208 (43.4) | 205 (42.8) | 0.043 | 340 (35.5) | 618 (64.5) | 1.13 (0.98–1.29) |
Abbreviations: BP (WTCCC) cases, bipolar disorder cases in the WTCCC analysis; CI, confidence interval; OR, odds ratio; SZ cases, schizophrenia cases; UP cases, unipolar recurrent major depression cases; WTCCC, Wellcome Trust Case Control Consortium.