Figure 6.

CEP-37247 is at least as potent as etanercept in the Tg197 transgenic mouse model. Mean arthritic scores for the treatment of 24 groups of 8 Tg197 mice across three separate studies were compared. Mice were treated with CEP-37247 (three groups each at doses of 0.3, 1, 3 and 10 mg/kg) and etanercept (three groups each at doses of 0.3, 1, 3 and 10 mg/kg). In each study, the mean arthritic score at week 10 for each treatment group was compared to the mean arthritic score for treatment with the IgG1 irrelevant isotype control (palivizumab, 10 mg/kg) and a percentage response score calculated. The percentage response scores for treatment with both CEP-37247 (red triangle) and etanercept (black square) are plotted.