Table 1A.
Summary of mean (±SD) pharmacokinetic parameters determined for the administration of a single intravenous dose to a group of three male and three female cynomolgus macaques
| IV dose level 50 mg/kg | Exposure AUC0-336 h (ng.h/mL) | Maximum concentration Cmax (ng/mL) | Time of maximum concentration tmax (h) | Elimination half-life t1/2 (h) | Clearance CL (mL/hr/kg) | Volume of distribution Vz (mL/kg) |
| Males | ||||||
| Number | 3 | 3 | 3 | 3 | 3 | 3 |
| Mean | 46000000 | 1320000 | 0.167 | 104 | 0.985 | 148 |
| SD (n-1) | 1650000 | 36100 | 0.00 | 5.33 | 0.0365 | 10.1 |
| CV% | 3.6 | 2.7 | 0.0 | 5.1 | 3.7 | 6.8 |
| Females | ||||||
| Number | 3 | 3 | 3 | 3 | 3 | 3 |
| Mean | 43300000 | 1020000 | 0.211 | 97.4 | 1.06 | 149 |
| SD (n-1) | 1410000 | 116000 | 0.0770 | 9.52 | 0.0433 | 12.7 |
| CV% | 3.3 | 11.3 | 36.5 | 9.8 | 4.1 | 8.5 |
Parameters presented are detailed in the text.