Table 1. Key High-Resolution Structures with Relevance for Neurobiologists: Channels, Transporters, and Receptors.
Resolutiona | Reference | ||
---|---|---|---|
Ligand-gated ion channels: whole channels | Torpedo marmorata nicotinic acetylcholine receptor | 4.0 Å | Miyazawa et al., 2003 |
Ligand-gated ion channels: extracellular domains | Mollusc AChBPs | ||
Limnea stagnalis AChBP | 2.7 Å | Brejc et al., 2001 | |
Limnea stagnalis AChBP: conotoxin complex | 2.4 Å | Celie et al., 2005a | |
Limnea stagnalis AChBP: carbamoylcholine and nicotine complexes | 2.2 Å | Celie et al., 2004 | |
Glutamate receptors: extracellular domains | |||
AMPA (GluR2) | 1.9 Å | Armstrong et al., 1998 | |
AMPA (GluR2): agonist, antagonist, and modulator complexes | 2.1 Å | Sun et al., 2002 | |
Kainate R (GluR5): antagonist complexes | 1.74 Å | Mayer et al., 2006 | |
Kainate R (GluR6): agonist complexes | 1.65 Å | Mayer, 2005a | |
NMDAR (NR1/NR2A heteromer) | 1.88 Å | Furukawa et al., 2005 | |
Potassium channels: whole channels | Rat Kv1.2/Kvβ complex | 2.9 Å | Long et al., 2005 |
Archaeal voltage-gated channel KvAP | 3.2 Å | Jiang et al., 2003 | |
Bacterial potassium channel: KcsA | 2.0 Å | Zhou et al., 2001 | |
Bacterial potassium channel MthK | 3.3 Å | Jiang et al., 2002 | |
Bacterial inward rectifier KirBac1.1 | 3.65 Å | Kuo et al., 2003 | |
Bacterial nonselective cation channel NaK | 2.4 Å | Shi et al., 2006 | |
Potassium channel intracellular domains and regulatory complexes | Kv4.3/KChIP1 complex | 3.2 Å |
Pioletti et al., 2006; Wang et al., 2007 |
Kir3.1 intracellular domain | 1.8 Å | Nishida and MacKinnon, 2002 | |
HERG PAS domain | 2.6 Å | Morais Cabral et al., 1998 | |
SK channel intracellular domain: Ca2+/CaM complex | 1.6 Å | Schumacher et al., 2001 | |
Voltage-gated calcium channels: intracellular domains | CaVβ and CaVβ-AID complex | 2.0 Å |
Chen et al., 2004; Opatowsky et al., 2004; Van Petegem et al., 2004 |
Ca2+/CaM-CaV1.2 IQ domain complex | 2.0 Å |
Fallon et al., 2005; Van Petegem et al., 2005 |
|
Cyclic nucleotide gated channels | HCN2 Cyclic nucleotide binding domain/cAMP | 2.0 Å | Zagotta et al., 2003 |
HCN2 Cyclic nucleotide binding domain/cGMP | 1.9 Å | Zagotta et al., 2003 | |
TRP Channels | N-terminal Ankyrin repeat domain TRPV2 | 1.6 Å |
Jin et al., 2006; McCleverty et al., 2006 |
TRPM7 kinase domain | 2.4 Å | Yamaguchi et al., 2001 | |
Chloride channels: whole channel | Bacterial chloride channel | 3.0 Å | Dutzler et al., 2002 |
Chloride channel intracellular domains | Human ClC-5 CBS domain (ATP and ADP) | 2.3 Å | Meyer et al., 2007 |
Ca2+ ATPase | No nucleotide, with calcium | 2.6 Å | Toyoshima et al., 2000 |
Magnesium fluoride | 2.3 Å | Toyoshima et al., 2004 | |
G protein-coupled receptors | Rhodopsin | 2.8 Å | Palczewski et al., 2000 |
G protein-coupled receptors: extracellular domains | mGluR1 ligand binding domain: apo and gluatmate complex | 2.2 Å | Kunishima et al., 2000 |
mGluR1 ligand binding domain: antagonist complex | 3.3 Å | Tsuchiya et al., 2002 | |
Amino acid transporters | Archaeal glutamate transporter | 3.5 Å | Yernool et al., 2004 |
Archaeal asparate transporter | 1.65 Å | Yamashita et al., 2005 |
Where multiple similar structures are solved, the highest resolution obtained is indicated.