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. Author manuscript; available in PMC: 2010 Dec 29.
Published in final edited form as: Neuron. 2007 Mar 1;53(5):663–675. doi: 10.1016/j.neuron.2007.02.010

Figure 2. Hydrophobic and Electrostatic Contacts in the Kv7.4 Coiled-Coil Domain.

Figure 2

(A) Hydrophobic layers of the coiled-coil core. Van der Waals spheres depicting the side chains of the “a” (blue) and “d” (pink) layers on a ribbon backbone (gray) are shown. The N- and C-terminal ends of the coiled coil are indicated.

(B) Geometry of individual coiled-coil “a” and “d” layers. Top pictograms represent “a” (right) and “d” layers (left). Arrows show the direction from the N to C terminus, open circles represent the Cα atoms, and black circles the Cβ atoms. Ball-and-stick representations show each layer of the core. Van der Waals spheres indicate core residues, colored as in (A).

(C) Intra- and intermolecular electrostatic interactions. Ribbon diagram of tetramer with helices colored as in Figure 1D shows network 1 and network 2 interactions between the side chains (shown as sticks) of the green and orange subunits. Salt bridges (black lines) and hydrogen bonds (dotted lines) are indicated. Side chain labels are color coded to indicate the subunit of origin.