Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model for regulation of Sp1-mediated transcription by the competing activities of MDM2 and pRB. During normal growth of wild-type cells, the level of transcriptionally active Sp1 is established by the levels of MDM2 and pRB. However, in cells where MDM2 has been amplified, pRB becomes limiting and as a consequence more Sp1 is bound to MDM2 and thus lowering gene expression from Sp1-dependent promoters.
