. Author manuscript; available in PMC: 2010 Dec 29.

Published in final edited form as: J Pathol. 2004 Nov;204(4):438–449. doi: 10.1002/path.1650

Table 1.

Neurodegenerative diseases with neuronal intermediate filament- and tau-positive filamentous inclusions

Neuronal intermediate filaments	Tau
Alzheimer’s disease^* Amyotrophic lateral sclerosis Charcot–Marie–Tooth disease Diabetic neuropathy Dementia with Lewy bodies^* Giant axonal neuropathy Neuronal intermediate filament Inclusion disease Parkinson’s disease^*	Alzheimer’s disease Amyotrophic lateral sclerosis/parkinsonism–dementia complex of Guam (ALS/PDC)^† Argyrophilic grain disease^† Corticobasal degeneration^† Dementia pugilistica^† Diffuse neurofibrillary tangles with calcification^† Down’s syndrome Frontotemporal dementia with parkinsonism linked to chromosome 17^† Gerstmann–Sträussler–Scheinker disease Myotonic dystrophy Niemann–Pick disease, type C Non-Guamanian motor neuron disease with neurofibrillary tangles Pick’s disease^† Post-encephalitic parkinsonism Prion disease with neurofibrillary tangles Progressive supranuclear palsy^† Subacute sclerosing panencephalitis Tangle only dementia^†

Neuronal intermediate filaments

Tau

Alzheimer’s disease^* Amyotrophic lateral sclerosis
Charcot–Marie–Tooth disease
Diabetic neuropathy
Dementia with Lewy bodies^*
Giant axonal neuropathy
Neuronal intermediate filament
Inclusion disease
Parkinson’s disease^*

Alzheimer’s disease
Amyotrophic lateral
sclerosis/parkinsonism–dementia
complex of Guam (ALS/PDC)^†
Argyrophilic grain disease^†
Corticobasal degeneration^†
Dementia pugilistica^†
Diffuse neurofibrillary tangles with calcification^†
Down’s syndrome
Frontotemporal dementia with parkinsonism linked to chromosome 17^†
Gerstmann–Sträussler–Scheinker disease
Myotonic dystrophy
Niemann–Pick disease, type C
Non-Guamanian motor neuron disease with neurofibrillary tangles
Pick’s disease^†
Post-encephalitic parkinsonism
Prion disease with neurofibrillary tangles
Progressive supranuclear palsy^†
Subacute sclerosing panencephalitis
Tangle only dementia^†

Neuronal intermediate filaments are chaperone proteins and a minor component of inclusions.

^†

Diseases in which neurofibrillary pathology is the most predominant neuropathological feature.