Table 1.

Effect of reaction conditions on Pd/P(t-Bu)₃-catalyzed Suzuki cross-couplings.

entry	boronic acid	KF	added water	yield (%)a
1	recrystallized from water	dryb	none	96
2	driedc	dryb	none	14
3	driedc	dryb	1 equiv	87
4	driedc	dryb	2 equiv	88
5	driedc	dryb	4 equiv	92
6	driedc	dihydrate	none	94
7	recrystallized from water	dihydrate	none	97
8	as received	dihydrate	none	97
9	recrystallized from water	dihydrate	2 equiv	97

All data are the average of two experiments.

^aThe yield was determined by ¹H NMR spectroscopy vs. an internal standard.

^bAnhydrous (Aldrich).

^cHeated at 120 °C at 300 mtorr for 1.0 h.