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. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: Biol Psychiatry. 2010 Nov 15;68(10):903–912. doi: 10.1016/j.biopsych.2010.08.025

Figure 1.

Figure 1

(A) A representative 2-D DIGE image of CSF from the discovery cohort. Samples were depleted of six highly abundant proteins, fluorescently labeled, and subjected to isoelectric focusing followed by SDS-PAGE. YKL-40 is more abundant in four spots in the CDR 1 group (labeled 1–4 in the inset, with mean fold changes of 1.41, 1.50, 1.46, 1.32, respectively). The near invisibility of spot 4 in this printed representation illustrates the great sensitivity of 2-D DIGE to detect proteins of low abundance. (B) Sequence coverage of human YKL-40 by mass spectrometry. Indicated in red is the compilation of peptides identified in the four spots. The signal sequence is shown in green, and polymorphisms are indicated by boxes.