. 2010 Nov 17;173(2):201–216. doi: 10.1093/aje/kwq345

Table 3.

Body Size and Breast Cancer Risk in Premenopausal Women, by Race/Ethnicity^a, in the San Francisco Bay Area Breast Cancer Study, 1995–2004

	All				Hispanics				African Americans				Non-Hispanic Whites
	No. of Cases (n = 672)	No. of Controls (n = 808)	OR^b	95% CI	No. of Cases (n = 375)	No. of Controls (n = 483)	OR^c	95% CI	No. of Cases (n = 154)	No. of Controls (n = 160)	OR^c	95% CI	No. of Cases (n = 143)	No. of Controls (n = 165)	OR^c	95% CI
Current height, cm^d
Quartile 1	109	202	1.0		61	122	1.0		25	42	1.0		30	42	1.0
Quartile 2	147	202	1.69	0.86, 1.69	87	120	1.38	0.88, 2.15	37	38	1.51	0.71, 3.21	34	43	1.14	0.53, 2.42
Quartile 3	196	202	2.22	1.13, 2.22	84	121	1.23	0.78, 1.94	59	40	2.55	1.24, 5.21	34	39	1.38	0.65, 2.95
Quartile 4	220	202	2.53	1.23, 2.53	143	120	1.84	1.18, 2.85	33	40	1.39	0.65, 2.94	45	41	1.81	0.87, 3.74
P_trend			<0.01				0.01				0.20				0.09
Quartile of current weight, kg^e
≤61.2	227	229	1.0		134	125	1.0		31	27	1.0		62	77	1.0
61.3–68.0	148	182	0.76	0.56, 1.04	86	121	0.61	0.40, 0.93	35	34	0.70	0.31, 1.56	27	27	1.25	0.60, 2.60
68.1–81.6	181	214	0.70	0.52, 0.95	102	146	0.48	0.32, 0.73	41	37	0.75	0.35, 1.62	38	31	1.86	0.94, 3.70
>81.6	116	183	0.51	0.36, 0.72	53	91	0.43	0.26, 0.69	47	62	1.62	0.26, 1.14	16	30	0.55	0.23, 1.34
P_trend			<0.01				<0.01				0.13				0.96
Current BMI^f,^g
<25.0	298	262	1.0		146	118	1.0		59	46	1.0		93	98	1.0
25.0–29.9	195	274	0.65	0.49, 0.85	125	190	0.56	0.38, 0.81	40	50	0.54	0.29, 1.03	30	34	1.02	0.54, 1.93
≥30.0	179	272	0.60	0.45, 0.79	104	175	0.52	0.35, 0.77	55	64	0.65	0.35, 1.23	20	33	0.60	0.28, 1.30
P_trend			<0.01				<0.01				0.20				0.28
Current body build
1–3 (slim)	123	104	1.0		65	55	1.0		21	13	1.0		37	36	1.0
4	153	173	0.74	0.52, 1.06	75	95	0.76	0.45, 1.28	37	41	0.40	0.14, 0.94	41	37	0.86	0.40, 1.82
5–6	301	357	0.73	0.52, 1.00	185	239	0.68	0.43, 1.06	68	55	0.64	0.26, 1.54	48	63	0.80	0.40, 1.59
7–9 (heavy)	91	170	0.40	0.27, 0.60	46	92	0.40	0.23, 0.71	28	49	0.25	0.10, 0.65	17	29	0.39	0.16, 0.98
P_trend			<0.01				<0.01				0.03				0.08
Quartile of young-adult weight, kg^h
≤53.5	180	205	1.0		118	132	1.0		24	26	1.0		38	47	1.0
53.6–58.3	194	185	1.10	0.81, 1.50	113	109	1.03	0.68, 1.55	39	32	1.56	0.66, 3.71	42	44	1.67	0.79, 3.56
58.4–63.5	159	202	0.77	0.56, 1.07	78	122	0.59	0.38, 0.90	47	41	1.16	0.52, 2.59	34	39	1.19	0.55, 2.57
>63.5	131	188	0.65	0.46, 0.92	61	95	0.56	0.35, 0.90	43	59	0.68	0.30, 1.52	27	34	1.12	0.47, 2.68
P_trend			<0.01				<0.01				0.12				0.96
Quartile of young-adult BMIⁱ
≤20.9	210	195	1.0		95	85	1.0		41	42	1.0		74	68	1.0
21.0–22.7	200	195	1.07	0.80, 1.44	121	105	1.29	0.84, 1.99	48	37	1.67	0.83, 3.35	31	53	0.52	0.28, 0.96
22.8–24.9	136	195	0.79	0.57, 1.08	81	128	0.74	0.48, 1.17	37	41	0.97	0.49, 1.93	18	26	0.86	0.39, 1.91
>24.9	118	195	0.73	0.52, 1.01	73	140	0.65	0.41, 1.04	27	38	0.87	0.41, 1.86	18	17	1.03	0.43, 2.46
P_trend			0.02				0.01				0.42				0.77
Weight change, kg^j
Loss >3.0	24	33	0.57		13	17	0.57		7	6	1.17		4	10	0.35
None/stable	146	115	1.0	0.31, 1.06	82	57	1.0	0.24, 1.36	23	17	1.0	0.28, 4.91	41	41	1.0	0.09, 1.38
Gain 3.1–10.0	217	240	0.73	0.53, 1.02	119	142	0.60	0.38, 0.95	45	48	0.61	0.27, 1.39	53	50	1.35	0.69, 2.65
Gain 10.1–20.0	155	205	0.54	0.38, 0.76	94	138	0.40	0.25, 0.65	34	33	0.68	0.28, 1.62	27	34	0.87	0.40, 1.90
Gain >20.0	122	187	0.44	0.30, 0.63	62	104	0.35	0.21, 0.59	44	54	0.52	0.22, 1.22	16	29	0.57	0.22, 1.45
P_trend^k			<0.01				<0.01				0.32				0.23
Quartile of waist circumference, cm
≤78.7	192	197	1.0		103	95	1.0		17	23	1.0		72	79	1.0
78.8–87.0	132	190	0.77	0.56, 1.07	76	131	0.59	0.38, 0.91	31	31	1.60	0.65, 3.93	25	28	0.96	0.46, 1.98
87.1–98.0	155	193	0.87	0.63, 1.21	93	135	0.71	0.46, 1.10	42	30	1.89	0.79, 4.50	20	28	0.75	0.35, 1.65
>98.0	154	191	0.80	0.57, 1.12	91	110	0.74	0.47, 1.17	47	60	1.09	0.47, 2.52	16	21	0.90	0.37, 2.17
P_trend			0.30				0.35				0.87				0.59
Quartile of hip circumference, cm
≤99.5	153	194	1.0		85	116	1.0		16	20	1.0		52	58	1.0
99.6–106.6	164	191	1.16	0.84, 1.60	106	127	1.20	0.78, 1.83	27	27	1.58	0.60, 4.18	31	37	1.08	0.54, 2.17
106.7–116.3	170	194	1.00	0.72, 1.38	93	126	0.87	0.56, 1.35	51	38	1.51	0.62, 3.70	26	30	1.07	0.51, 2.27
>116.3	146	191	0.91	0.65, 1.28	79	102	1.01	0.63, 1.61	43	58	0.91	0.37, 2.22	24	31	0.97	0.44, 2.15
P_trend			0.43				0.64				0.46				0.99
Quartile of waist-to-hip ratio
≤0.77	223	202	1.0		103	88	1.0		33	29	1.0		87	85	1.0
0.78–0.81	137	199	0.62	0.45, 0.85	86	125	0.63	0.41, 0.97	28	36	0.61	0.27, 1.37	23	38	0.55	0.28, 1.10
0.82–0.85	117	178	0.64	0.45, 0.89	78	126	0.64	0.41, 1.00	29	30	0.83	0.37, 1.86	10	22	0.40	0.15, 1.02
>0.85	156	190	0.78	0.56, 1.08	96	131	0.71	0.46, 1.11	47	48	0.82	0.39, 1.74	13	11	1.35	0.47, 3.86
P_trend			0.15				0.19				0.90				0.38
Quartile of waist-to-height ratio
≤0.50	234	221	1.0		110	96	1.0		34	32	1.0		90	93	1.0
0.51–0.55	121	187	0.62	0.45, 0.86	71	120	0.56	0.36, 0.88	33	43	0.78	0.37, 1.64	17	24	0.57	0.26, 1.24
0.56–0.61	137	176	0.88	0.63, 1.23	91	133	0.79	0.50, 1.23	33	21	1.68	0.73, 3.85	13	22	0.70	0.29, 1.67
>0.61	141	187	0.76	0.54, 1.06	91	122	0.74	0.47, 1.17	37	48	0.80	0.37, 1.72	13	17	0.73	0.29, 1.89
P_trend			0.31				0.47				0.95				0.27

Abbreviations: BMI, body mass index; CI, confidence interval; OR, odds ratio.

All P values for interaction by race/ethnicity were >0.05.

Adjusted for age (continuous), race/ethnicity (Hispanic, African American, non-Hispanic white), place of birth (US-born, foreign-born), education level (some high school or less, high school graduate or vocational/technical school, some college, college graduate), family history of breast cancer (no, yes), personal history of benign breast disease (no, yes), years of age at menarche (≤11, 12, 13, ≥14), number of full-term pregnancies (0, 1, 2, 3, ≥4), months of breastfeeding (nulliparous, 0, ≤6, 7–12, 13–24, >24), lifetime physical activity (quartiles according to the distribution among premenopausal controls), average daily grams of alcohol consumption (0, 0.1–4.9, 5–9.9, 10–19.9, ≥20), average daily total caloric intake (quartiles according to the distribution among premenopausal controls), and current height (quartiles according to the distribution among premenopausal controls).

Adjusted for above variables except for race/ethnicity.

Based on measured height (or self-reported adult height when measured height not available). Quartile cutpoints for all race/ethnicities combined are ≤154.6, 154.7–159.3, 159.4–164.6, and >164.6. Analyses in each racial/ethnic group are based on race-specific quartiles of height among controls. Quartile cutpoints by race/ethnicity are ≤152.4, 152.5–156.7, 156.8–160.5, and >160.5 for Hispanics, ≤159.9, 160.0–163.9, 164.0–169.3, and >169.3 for African Americans, and ≤159.6, 159.7–164.0, 164.1–168.1, and >168.1 for non-Hispanic whites.

Based on self-reported weight (or measured weight when self-reported weight not available).

Based on self-reported weight and measured height (if not available, then based on measured weight and/or self-reported height).

BMI is determined as weight in kilograms divided by height in meters squared.

Between ages 25–30 for cases diagnosed from April 1995 to April 1998 and matched controls and between ages 20–29 for cases diagnosed from May 1998 to April 2002 and matched controls.

ⁱ

Based on usual weight in a woman's 20s and measured height at interview (or self-reported adult height when measured height not available).

Self-reported weight (or measured weight if self-reported weight not available) at interview minus self-reported usual weight in a woman's 20s.

P for trend excludes women with loss of >3.0 kg.