FIG. 1.

Working hypothesis of the interaction between regenerating tissue and an epithelial cancer. The effect of adipose-derived stem cell administration on active breast cancer is depicted here. Introduction of ASC, which self-replicate and give rise to adipose, vessels, and stroma, promotes the growth of active tumor (purple) and induces motility and upregulation of adhesion molecules, promoting invasion and metastasis (deep purple). Dormant cancer cells, shown here nested in a normal breast duct (hot pink, inset), are unaffected by the wound healing signals resulting from regenerative therapy. ASC, adipose-derived stem cells. Color images available online at www.liebertonline.com/ten.