. 2010 Oct 26;16(6):567–575. doi: 10.1089/ten.teb.2010.0352

Table 1.

Functional and Phenotypic Characteristics of Mesenchymal and Adipose-Derived Stem Cells

	MSC	ASC
Developmental origin	Mesoderm, neural crest	Mesoderm, neural crest
Tissue of origin	BM	White adipose tissue
Selection	Plastic adherence	Plastic adherence
Principal antigenic markers (in vitro)	CD10, CD13, CD29, CD44, CD49a-f, CD63, CD73, CD90, CD105, CD106, CD140b, CD146, CD166, CD271, STRO-1^45,75–86	CD10, CD13, CD29, CD34, CD44, CD49a, CD63, CD73, CD90, CD105, CD106, CD140b, CD146, CD166, CD271, STRO-1^19,83–90
Differentiation potential	Adipose tissue^91,a	Adipose tissue^87,a
	Bone^91,a	Bone^87,a
	Cartilage^91,a	Cartilage^87,a
	Smooth muscle^92,a	Smooth muscle^93,94
	Skeletal muscle⁹⁵	Skeletal muscle^87,a
	Cardiac muscle⁹⁶	Cardiac muscle⁹⁷
	Endothelium⁹⁸	Endothelium^15,16
	Neurons⁹⁹	Neurons¹⁰⁰
	Hepatocytes¹⁰¹	Hepatocytes¹⁰²
	Epithelium¹⁰³	Epithelium¹⁰⁴
Telomerase	Absent^105–107	Absent or low^108,109
Expansion in vitro	20–50 population doublings¹¹⁰	44–80 population doublings^17,111
Precursors in vivo	Pericytes (subendothelial reticular cells, CD146+)^76,112	CD34+ Supra-adventitial, pericytes¹⁸
Frequency estimate in vivo (percent of nucleated cells)	0.001%–0.004%^20,46	2%–27%¹⁸

^{^a}

Multipotentiality demonstrated at the clonal level.

ASC, adipose-derived stem cell; BM, bone marrow; MSC, mesenchymal stem cell.