Table 1.
MSC | ASC | |
---|---|---|
Developmental origin | Mesoderm, neural crest | Mesoderm, neural crest |
Tissue of origin | BM | White adipose tissue |
Selection | Plastic adherence | Plastic adherence |
Principal antigenic markers (in vitro) | CD10, CD13, CD29, CD44, CD49a-f, CD63, CD73, CD90, CD105, CD106, CD140b, CD146, CD166, CD271, STRO-145,75–86 | CD10, CD13, CD29, CD34, CD44, CD49a, CD63, CD73, CD90, CD105, CD106, CD140b, CD146, CD166, CD271, STRO-119,83–90 |
Differentiation potential | Adipose tissue91,a | Adipose tissue87,a |
Bone91,a | Bone87,a | |
Cartilage91,a | Cartilage87,a | |
Smooth muscle92,a | Smooth muscle93,94 | |
Skeletal muscle95 | Skeletal muscle87,a | |
Cardiac muscle96 | Cardiac muscle97 | |
Endothelium98 | Endothelium15,16 | |
Neurons99 | Neurons100 | |
Hepatocytes101 | Hepatocytes102 | |
Epithelium103 | Epithelium104 | |
Telomerase | Absent105–107 | Absent or low108,109 |
Expansion in vitro | 20–50 population doublings110 | 44–80 population doublings17,111 |
Precursors in vivo | Pericytes (subendothelial reticular cells, CD146+)76,112 | CD34+ Supra-adventitial, pericytes18 |
Frequency estimate in vivo (percent of nucleated cells) | 0.001%–0.004%20,46 | 2%–27%18 |
Multipotentiality demonstrated at the clonal level.
ASC, adipose-derived stem cell; BM, bone marrow; MSC, mesenchymal stem cell.