Figure 4. LVSCE/AMVAD vaccine partially protects against i.n. F. tularensis LVS challenge.

The remaining naïve, and LVSCE, LVSCE/AMVAD or LVSCE/CT immunized groups of mice (n = 15) in Figure 1 experiment, were intranasally challenged with F. tularensis LVS (3.4×10⁴ cfu) at 35 d (14 d post the last immunization). The % change in body weight (A), clinical scores (B) and % survival (C) of sub-groups of 5 mice per each group was recorded over a 22 d period subsequent to the challenge. The data are presented as mean ± SD for each group (n = 5) for panels A and B. ^** p<0.01 vs. LVSCE alone immunized group. Data are representative of two separate experiments.