Table 2. Relative risk of gastrointestinal bleeding according to regular use of aspirin^†.

	Non-Regular users	Regular users	P Value
All Cases *
Person-years	176496	200735
No of cases	244	463
Age-adjusted RR (95% CI)	1.0	1.36 (1.16–1.60)	<.001
Multivariate RR (95% CI)‡	1.0	1.32 (1.12–1.55)	0.001
Upper GI Bleeding
Person-years	176496	200735
No of cases	99	204
Age-adjusted RR (95% CI)	1.0	1.53 (1.19–1.97)	<.001
Multivariate RR (95% CI)‡	1.0	1.49 (1.16–1.92)	0.002
Lower GI Bleeding
Person-years	176496	200735
No of cases	110	193
Age-adjusted RR (95% CI)	1.0	1.26 (0.99–1.62)	0.063
Multivariate RR (95% CI)‡	1.0	1.22 (0.95–1.56)	0.124

^†Regular aspirin use is defined as consumption of ≥2 times per week. Non-regular use is defined as consumption of <2 times per week. Relative risks (RR) are compared to non-regular users as reference group.

*Includes 101 individuals with unknown or unspecified location of GI bleeding.

^‡Multivariate RR model is adjusted for age, NSAID use (yes or no), smoking status (never, past, current), body mass index (<21. 21–22.9, 23–24.9, 25–29.9, ≥30 kg/m²), exercise (<1.7, 1.7–4.5, 4.6–10.5, 10.6–22.0, ≥22.1 mets/week), alcohol (0, 0.1–4.9, 5–14.9, ≥15 g/day).