Table 2. Endothelial-biomarkers are associated with retinopathy in a cohort of children with cerebral malaria (CM).

	AUROC CM-R vs CM-N	p-value	Cutoff	Sensitivity (95%CI)	Specificity (95%CI)	Positive likelihood ratio (95% CI)	Negative likelihood ratio (95% CI)
Ang-1	0.64 (0.51–0.78)	0.046	3.2	68 (53–81)	44 (28–62)	1.2 (0.84–1.8)	0.70 (0.38–1.3)
Ang-2	0.77 (0.65–0.89)	<0.0001*	6.2	71 (55–83)	72 (54–85)	2.6 (1.4–4.8)	0.40(0.23–0.69)
Ang-2:Ang-1	0.74 (0.60–0.87)	0.001*	2.0	74 (58–85)	66 (47–80)	2.1 (1.3–3.7)	0.40 (0.22–0.73)
sTie-2	0.83 (0.73–0.93)	<0.0001*	56	74 (58–85)	72 (54–85)	2.7 (1.4–5.0)	0.36 (0.20–0.65)
VWF propeptide	0.71 (0.58–0.85)	0.005*	51	76 (61–87)	62 (44–77)	2.0 (1.2–3.3)	0.38 (0.20–0.72)
VWF	0.58 (0.42–0.73)	0.305	310	68 (53–81)	58 (41–74)	1.7 (1.0–2.7)	0.54 (0.31–0.94)
sICAM-1	0.73 (0.59–0.86)	0.006*	1000	71 (55–83)	69 (51–83)	2.3 (1.3–4.1)	0.42 (0.24–0.73)
VEGF	0.65 (0.52–0.79)	0.040	0.25	74 (58–85)	58 (39–74)	1.7 (1.1–2.8)	0.46(0.24–0.85)
IP-10	0.58 (0.43–0.73)	0.312	0.71	66 (50–79)	54 (36–70)	1.4 (0.90–2.2)	0.64 (0.37–1.1)

Median (range), Mann-Whitney U test;

*p<0.05 after Holms correction for 9 pair-wise comparisons;

CM-R: Cerebral malaria, retinopathy positive

CM-N: Cerebral malaria, retinopathy negative, AUROC: Area under the receiver operating characteristic curve.