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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Prog Lipid Res. 2010 Oct 21;50(1):115–131. doi: 10.1016/j.plipres.2010.10.005

Figure 5. Pro- and anti-atherogenic effects of various 12- and 15-lipoxygenase lipid metabolites.

Figure 5

The controversial effects of different 12- and 15-LOX isoforms on the development of atherosclerosis in different animal models or in human epidemiological studies may be due to both pro-and anti-atherogenic effects mediated via particular lipid metabolites. While 12-LOX - generated lipid products such as 13-HODEs and 12(S) HETEs have more unanimously atherogenic effects, both 15-LOX-1 and 15-LOX-2 may have pro- or anti-atherogenic effects depending on metabolites formed and the specific cell type and animal model. For example, 15-LOX-1 may generate lipoxins, protectins and resolvins that are associated with resolution of inflammation in vasculature. However, both 15-LOX-1 and 15-LOX-2 produce 15-HETEs that can exert anti-inflammatory effects by antagonizing the effects of leukotriene B4 on polymorphonuclear cells and inhibiting their trans-endothelial migration in response to cytokines.