Table 1.

Clinical and biochemical characteristics of the study subjects

Factor	Controls (n=25)	Steatosis (n=11)	NASH (n=24)	P value
Age (years)	42.0 (9.4)	43.5 (10.7)	43.6 (12.6)	NS
Male	7 (28)	6 (54.6)	8 (33.3)	NS
Body Mass Index (kg/m²)	23.3 (2.7)	34.0 (4.0)^*	34.8 (4.7)^*	<0.001
Triglycerides (mg/dL)	77.0 (64.0, 93.0)	159.0 (115.0, 174.0)^*	160.0 (94.5, 216.5)^*	0.007
Glucose (mmol/L)	4.7 (4.4, 4.8)	5.0 (4.5, 5.3)	5.1 (4.7, 5.5)^*	0.015
Insulin (pmol/L)	50.0 (39.4, 64.4)	111.6 (95.8, 188.9)^*	147.0 (113.3, 236.1)^*	<0.001
AST	22.0 (18.0, 27.0)	30.0 (19.0, 37.0)	47.0 (32.0, 76.5)^†	<0.001
ALT	16.0 (13.0, 22.0)	35.0 (21.0, 61.0)^*	58.0 (46.0, 118.5)^* ^†	<0.001
Total homocysteine (μmol/L)^#	6.5 (5.7, 8.9)	7.4 (6.7, 9.0)	8.8 (7.9, 10.6)^*	0.006
eGFR	86.3 (79.7, 96.2)	81.4 (74.1, 84.1)	88.6 (73.3, 97.0)	NS

Statistics presented are Mean (SD), Median (Q25, Q75) or N (%)

Measured for 20 controls, 11 steatosis and 23 NASH patients.

Significantly different from controls;

^†

Significantly different from controls and steatosis group (p<0.017)

eGFR: estimated glomarular filtration rate (calculated as described in Methods)