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Progressive decline of β-cell function (measured by C-peptide) is evident even in studies that are successful. These include intervention with the anti-CD3 monoclonal antibodies teplizumab (A) (21) and otelixizumab (B) (22), the anti-CD20 monoclonal antibody rituximab (C) (23), and a GAD vaccine with aluminum (Alum) adjuvant (D) (24). AUC, area under the curve.
