TABLE 1.
Consortia studying type 1 diabetes
| Consortium | Full name of consortium | Consortium activities | Consortium website |
|---|---|---|---|
| T1DGC | Type 1 Diabetes Genetics Consortium | T1DGC was established with the primary goal of organizing international efforts to identify genes that determine an individual's risk of type 1 diabetes (2). | www.t1dgc.org |
| TEDDY | The Environmental Determinants of Diabetes in the Young | The primary objective(s) of TEDDY is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes (3). | teddy.epi.usf.edu |
| nPOD | Network for Pancreatic Organ donors with Diabetes | The mission of nPOD is to characterize pancreata and related tissues from organ donors with type 1 diabetes or who are islet autoantibody positive and utilize the tissues to address key immunological, histological, viral, and metabolic questions related to how type 1 diabetes develops (4). | www.jdrfnpod.org |
| SEARCH | Search for Diabetes in Youth | SEARCH identifies cases of diabetes in children/youth <20 years of age in six geographically dispersed populations that encompass the ethnic diversity of the United States (5). | www.searchfordiabetes.org |
| TrialNet | Type 1 Diabetes TrialNet | TrialNet is an international network conducting studies that will improve the understanding of type 1 diabetes disease development and test interventions to interdict the type 1 diabetes disease process, particularly strategies for type 1 diabetes prevention (6). | www.diabetestrialnet.org |
| ITN | Immune Tolerance Network | ITN is an international consortium dedicated to the clinical evaluation of novel tolerogenic approaches for the treatment of autoimmune diseases (including type 1 diabetes), asthma, and allergic diseases, and the prevention of graft rejection (7). | www.immunetolerance.org |
| TRIGR | Trial to Reduce IDDM in the Genetically at Risk | TRIGR is testing whether weaning to a casein hydrolysate formula during the first 6–8 months of life—in place of cow's milk-based formula—reduces the incidence of autoimmunity and type 1 diabetes in genetically susceptible newborn infants (8). | trigr.epi.usf.edu/ |
| ICRs | Islet Cell Resource Centers | ICRs' goals are: 1) to provide high-quality islets for use in transplantation; 2) to optimize characterization of quality and effectiveness of islets transplanted into patients; and 3) to provide islets for basic science studies (9). | icr.coh.org/ |
| CITR | Collaborative Islet Transplant Registry | CITR is expediting progress and promoting safety in islet transplantation through the collection, analysis, and communication of comprehensive and current data on all such transplants performed in North America (10). | www.citregistry.org |
| CIT | Clinical Islet Transplantation Consortium | This consortium is implementing a program of clinical studies, accompanied by mechanistic studies, in islet transplantation with or without accompanying kidney transplantation, for the treatment of type 1 diabetes (11). | www.isletstudy.org |
| DirecNet | Diabetes Research in Children Network | DirecNet is investigating the potential use of glucose monitoring technology and its impact on the management of type 1 diabetes in children (12). | public.direc.net/ |
| EDIC | Epidemiology of Diabetes Interventions and Complications | EDIC is studying the clinical course and risk factors associated with long-term complications of type 1 diabetes in the Diabetes Control and Complications Trial (DCCT) cohort (13). | www.bsc.gwu.edu/bsc/studies/edic.html |