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mRNA expression of transcriptional activators and coactivators of mitochondrial biogenesis after chronic exercise. Results are from real-time PCR analyses in skeletal muscle samples. A: Nuclear respiratory factor 1 (NRF-1). B: NRF-2. C: Mitofusin-2 (MFN2). D: Mitochondrial transcription factor A (Tfam). All data are normalized per 18S rRNA. Numbers of animals are as described in Fig. 1. Data are means ± SEM. *P < 0.05. C, controls; r.U., relative units; T, trained mice.
