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Exendin-4 increases ATP content at high glucose in GK islets. Effects of exendin-4 and PP2 on ATP content in the presence of high glucose for 30 min in GK (A) and Wistar (B) islets. After preincubation in the presence of 2.8 mmol/l glucose for 30 min, islets were incubated in the presence of 2.8 or 16.7 mmol/l glucose with or without 100 nmol/l exendin-4, 10 μmol/l PP2, or both for 30 min. Data are expressed as means ± SE (n = 7–8). *P < 0.05; †P < 0.01.
