FIG. 8.

Enhanced Treg suppressive capacity in response to anti–IL-17. CD4⁺CD25⁺ and CD4⁺CD25⁻ T-cells purified from spleens of wild-type mice administered anti–IL-17 mAb intraperitoneally on alternate days for 10 days 4 weeks prior at age 6 weeks were incubated alone or in a 1:1 ratio with DCs and anti-CD3. Proliferation was assessed by incorporation of [³H] thymidine and means ± SE; percent suppression was calculated. Three mice were pooled in each of two separate experiments. *P < 0.05 (t test).