TABLE 2.
Over-represented canonical pathways identified in the proteomic analysis
| Canonical pathways | Significance | Ratio, % | Total genes |
|---|---|---|---|
| Mitochondrial dysfunction | 3.16 × 10−11 | 7.2 | 171 |
| Oxidative phosphorylation | 3.98 × 10−7 | 5.4 | 166 |
| Ubiquinone biosynthesis | 7.94 × 10−6 | 5.0 | 119 |
| Methane metabolism | 1.25 × 10−4 | 4.0 | 66 |
| Breast cancer regulation by stathmin1 | 1.59 × 10−4 | 4.6 | 199 |
| Integrin signaling | 1.99 × 10−4 | 3.5 | 200 |
| Butanoate metabolism | 6.31 × 10−4 | 3.0 | 132 |
| 14-3–3-mediated signaling | 6.31 × 10−4 | 4.4 | 114 |
| Propanoate metabolism | 7.94 × 10−4 | 3.1 | 130 |
| Citrate cycle | 7.94 × 10−4 | 5.2 | 58 |
| Valine, leucine and isoleucine degradation | 1.00 × 10−3 | 3.6 | 111 |
| Fatty acid metabolism | 1.25 × 10−3 | 2.6 | 192 |
| Phenylalanine metabolism | 1.25 × 10−3 | 2.8 | 109 |
| Ketone body biology | 2.51 × 10−3 | 10.5 | 19 |
| Fatty acid elongation | 5.01 × 10−3 | 4.4 | 45 |
| Induction of apoptosis by HIV1 | 6.31 × 10−3 | 4.6 | 65 |
Significance provides the confidence of the association as identified by the P value of the Fisher exact test. The ratio provides the percentage of proteins associated with the pathway that underwent a significant change. The total genes column refers to all known genes to be linked to the pathway (not necessarily identified by the proteomic screen).