. 2010 Sep 28;60(1):288–297. doi: 10.2337/db10-0818

TABLE 3.

Effect of diabetes and insulin therapy on representative proteins annotated to oxidative phosphorylation and mitochondrial dysfunction

Symbol	Protein description	Fold	Control	% Change
Symbol	Protein description	Diabetic	Diabetic + insulin	% Change
ATP5C1	ATP synthase, F1 complex, γ	0.90	1.29^*	143
ATP5D	ATP synthase, F1 complex, Δ subunit	0.69^*	0.92	133
ATP5F1	ATP synthase, F0 complex, subunit B1	0.92	1.31^*	142
ATP5I	ATP synthase, F0 complex, subunit E	0.75^*	0.81	108
COX2	Cytochrome c oxidase subunit 2	0.82	1.06	129
COX4I1	Cytochrome c oxidase subunit IV isoform 1^¶	0.71^*	0.89	125
COX5A	Cytochrome c oxidase subunit Va	0.83	1.28^*	154
CPT1A	Carnitine palmitoyltransferase 1A (liver)	0.51^*	0.77	172
CYCS	Cytochrome c, somatic	0.56^*	0.9	160
HSD17B10	Hydroxysteroid (17-β) dehydrogenase 10	0.71^*	1.14	160
ND4	NADH dehydrogenase, subunit 4 (complex I)	0.43^*	0.56^*	130
NDUFA10	NADH dehydrogenase 1 α subcomplex 10^§	0.73^*	0.79	108
NDUFA13	NADH dehydrogenase 1 α subcomplex, 13	0.35^*	0.59^*	168
NDUFB10	NADH dehydrogenase 1 β subcomplex, 10	0.94	1.4^*	148
NDUFS1	NADH dehydrogenase Fe-S protein 1	0.78	0.91	116
NDUFS2	NADH dehydrogenase Fe-S protein 2	0.48^*	0.54	113
NDUFS3	NADH dehydrogenase Fe-S protein 3^¶	0.64^*	0.84	131
NDUFS8	NADH dehydrogenase Fe-S protein 8	0.91	1.34^*	147
PRDX3	Peroxiredoxin 3	0.87	1.26^*	145
PRDX5	Peroxiredoxin 5	0.74^*	0.86	116
SOD2	Superoxide dismutase 2, mitochondrial^¶	0.73^*	1.08	148
UQCRC1	Ubiquinol-cytochrome c reductase I	0.87	1.26^*	145

Values shown are the mean and the asterisk (*) indicates proteins that showed a significant change in expression. Percent change represents effect of insulin treatment on the protein expression ratio measured from diabetic rats. Please see online supplementary Table 1 for more complete information.

¶Confirming references (8,16);

§Confirming reference (29).