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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: J Neurochem. 2010 Dec 2;116(2):291–303. doi: 10.1111/j.1471-4159.2010.07104.x

Figure 5. C57 strain comparison for behavior in tasks relevant to core ASD symptoms.

Figure 5

The social interaction, social novelty and marble burying behavior of 8 week old C57BL/10J and C57BL/6J mice were compared, N=8 per strain. (a) C57BL/6J mice exhibited a significant preference for social novelty that was not shared by C57BL/10J mice (*, p< 0.001). This difference was largely due to an increase in time spent in the middle chamber of the testing arena, which was significantly greater in C57BL/10J mice (**, p< 0.05). (b) Time spent sniffing a novel stranger mouse (C57BL/6J) did not differ among C57 subject strains. (c) In the test for social novelty, both C57 strains exhibited a significant preference for social novelty, since subject mice mice spent proportionally more time in the box containing the new mouse (stranger 2) relative to the box containing the old novel mouse (stranger 1) (*, p<0.01). (d) C57BL/6J and C57BL/10J mice buried a similar number of blue marbles with wood-chip bedding over 30 min in this test of compulsive behavior.