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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Dev Dyn. 2011 Jan;240(1):176–187. doi: 10.1002/dvdy.22521

Figure 5. Tgf-β signaling during valve development of Ltbp1L nulls.

Figure 5

Distribution of pSmad2 in E10.5 (A, A’), E12.5 (B, B’), E14 (C, C’) and E16.5 (D, D’) control (A, B, C, D) and Ltbp1L−/− (A’, B’, C’, D’) AVC. Box areas in A and A’ represent AV cushions (superior upper, inferior lower). Box areas in B, B’, D and D’ are magnified to show mesenchymal cell-specific attenuation of Smad2 phosphorilation. Arrows indicate nuclear accumulation of pSmad2. E-E’. Immunolocalization of periostin in control (E) and Ltbp1L−/− (E’) E14.5 mitral valves.