Table 4.
Crude and adjusted geometric mean hormone concentrations in venous umbilical cord blood by race, HUB Study 2004–2005
| African-American | White | ||||
|---|---|---|---|---|---|
| Geometric mean |
95% CI | Geometric mean |
95% CI | p-value | |
| (A) Crude | |||||
| Testosterone (ng/mL) | 1.63 | 1.51 –1.76 | 1.62 | 1.50 –1.75 | 0.91 |
| Androstanediol glucuronide (ng/mL) | 22.59 | 20.19 –25.29 | 21.46 | 18.44 –24.97 | 0.60 |
| Estradiol (pg/mL) | 6579.99 | 5652.20 –7660.07 | 6402.92 | 5255.45 –7800.92 | 0.83 |
| SHBG (nmol/L) | 16.54 | 14.96 –18.28 | 17.89 | 16.49 –19.40 | 0.24 |
| IGF-1 (ng/mL) | 72.27 | 63.88 –81.76 | 90.64 | 75.16 –109.29 | 0.04 |
| IGF-2 (ng/mL) | 473.72 | 454.72 –493.51 | 534.25 | 506.09 –563.97 | 0.0009 |
| IGFBP-3 (ng/mL) | 1450.87 | 1378.86 –1526.63 | 1719.01 | 1597.56 –1849.69 | 0.0003 |
| Molar ratios of | |||||
| Testosterone/SHBG | 0.34 | 0.30 –0.39 | 0.31 | 0.28 –0.35 | 0.29 |
| Estradiol/SHBG | 1.47 | 1.24 –1.74 | 1.31 | 1.078 –1.56 | 0.42 |
| IGF-1/IGFBP-3 | 0.18 | 0.16 –0.20 | 0.19 | 0.17 –0.22 | 0.52 |
| IGF-2/IGFBP-3 | 1.18 | 1.13 –1.23 | 1.12 | 1.07 –1.18 | 0.18 |
| IGF-1+IGF-2/IGFBP-3 | 1.37 | 1.32 –1.43 | 1.33 | 1.28 –1.38 | 0.26 |
| (B) Adjusted* | |||||
| Testosterone (ng/mL) | 1.69 | 1.57 –1.81 | 1.50 | 1.35 –1.66 | 0.09 |
| Androstanediol glucuronide (ng/mL) | 23.66 | 21.05 –26.60 | 19.66 | 16.57 –23.32 | 0.11 |
| Estradiol (pg/mL) | 6781.14 | 5820.93 –7899.73 | 6311.95 | 5042.13 –7901.56 | 0.63 |
| SHBG (nmol/L) | 16.09 | 14.65 –17.67 | 18.65 | 16.26 –21.39 | 0.11 |
| IGF-1 (ng/mL) | 71.85 | 63.01 –81.93 | 93.11 | 76.76 –112.94 | 0.04 |
| IGF-2 (ng/mL) | 474.76 | 455.34 –495.00 | 537.27 | 505.20 –571.37 | 0.003 |
| IGFBP-3 (ng/mL) | 1481.63 | 1406.92 –1560.32 | 1673.38 | 1550.84 –1805.60 | 0.02 |
| Molar ratios of | |||||
| Testosterone/SHBG | 0.36 | 0.33 –0.41 | 0.28 | 0.24 –0.33 | 0.01 |
| Estradiol/SHBG | 1.56 | 1.25 –1.85 | 1.23 | 0.97 –1.57 | 0.14 |
| IGF-1/IGFBP-3 | 0.18 | 0.16 –0.19 | 0.20 | 0.17 –0.23 | 0.19 |
| IGF-2/IGFBP-3 | 1.16 | 1.11 –1.21 | 1.16 | 1.09 –1.24 | 0.96 |
| IGF-1+IGF-2/IGFBP-3 | 1.35 | 1.30 –1.40 | 1.38 | 1.30 –1.46 | 0.52 |
| (C) Mutually adjusted* | |||||
| Testosterone (ng/mL) | 1.69 | 1.58 –1.80 | 1.50 | 1.36 –1.65 | 0.07 |
| Estradiol (pg/mL) | 6748.67 | 5827.22 –7815.81 | 6470.44 | 5211.46 –8033.57 | 0.77 |
| SHBG (nmol/L) | 15.95 | 14.54 –17.49 | 18.97 | 16.56 –21.72 | 0.06 |
| IGF-1 (ng/mL) | 78.34 | 70.97 –86.48 | 78.88 | 68.08 –91.39 | 0.95 |
| IGF-2 (ng/mL) | 484.98 | 469.08 –501.41 | 515.74 | 490.88 –541.85 | 0.06 |
| IGFBP-3 (ng/mL) | 1531.65 | 1474.79 –1590.70 | 1570.11 | 1484.22 –1660.96 | 0.51 |
*
adjusted for birth weight, placental weight, mother’s age and parity, and time of day of birth; additionally, testosterone, estradiol, and SHBG as well as IGF-1, IGF-2, and IGFBP-3 were mutually adjusted for each other