Table 2.
Dose-dependent anti-oedema activity of rimonabant and indomethacin in croton oil-induced ear dermatitis after 6 h
| Substance | Number of mice | Dose (µmol·cm−2) | Oedema (mg) Mean ± SD | % reduction | ID50 (µmol·cm−2) |
|---|---|---|---|---|---|
| Controls | 10 | – | 7.0 ± 1.0 | – | – |
| Rimonabant | 10 | 0.1 | 5.3 ± 0.6* | 24 | 0.34 |
| 10 | 0.3 | 3.4 ± 0.6** | 51 | ||
| 10 | 1.0 | 2.1 ± 0.7** | 70 | ||
| Indomethacin | 10 | 0.1 | 5.2 ± 0.4* | 26 | 0.26 |
| 10 | 0.3 | 3.0 ± 0.4** | 57 | ||
| 10 | 1.0 | 1.4 ± 0.3** | 80 |
*
P < 0.005,
**
P < 0.001, significantly different from control values; one-way anova.