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. 2011 Jan;162(1):111–125. doi: 10.1111/j.1476-5381.2010.01032.x

Figure 4.

Figure 4

Effects of peroxisome proliferator-activated receptor (PPAR) agonists on OGD-reoxygenation-induced podocyte necrosis and apoptosis. Cells were treated with gemfibrozil (10 µM), GW0742 (0.1 µM), pioglitazone (1 µM) or rosiglitazone (0.1 µM) as a single or repeated treatment, and then exposed to OGD (5 h)-reoxygenation (24 h). (A) Percentage of PI+ cells at the end of 5 h-OGD. (B) Percentage of apoptotic nuclei at the end of 24 h-reoxygenation. (C) Caspase 3 activity at the end of 24 h-reoxygenation. Results are expressed as mean ± SEmean of four experiments run in triplicate. *P < 0.05; **P < 0.01 versus control (vehicle alone). °P < 0.05 versus single treatment. Broken line indicates cells treated with vehicle alone.