Table 1.
Decrease of apoptosis | Decrease of cell loss | Decrease of caspase 3 activation | ||||
---|---|---|---|---|---|---|
Agonist | Single treatment | Repeated treatment | Single treatment | Repeated treatment | Single treatment | Repeated treatment |
Gemfibrozil | 3.6 ± 0.5 × 10−6 | 7.4 ± 0.1 × 10−8 | 3.5 ± 0.2 × 10−6 | 5.7 ± 1.2 × 10−8 | 4.4 ± 0.4 × 10−6 | 6.3 ± 0.7 × 10−8 |
GW0742 | 1.1 ± 0.2 × 10−8 | 9.5 ± 1.4 × 10−10 | 7.5 ± 0.6 × 10−9 | 4.1 ± 0.8 × 10−10 | 1.6 ± 0.2 × 10−8 | 6.9 ± 0.1 × 10−10 |
Pioglitazone | 2.4 ± 0.4 × 10−7 | 8.6 ± 1.0 × 10−9 | 3.0 ± 0.2 × 10−7 | 4.2 ± 0.4 × 10−9 | 1.9 ± 0.1 × 10−7 | 6.1 ± 0.1 × 10−9 |
Rosiglitazone | 5.6 ± 1.2 × 10−8 | 1.7 ± 0.1 × 10−9 | 7.5 ± 0.7 × 10−8 | 1.1 ± 0.1 × 10−9 | 7.7 ± 0.8 × 10−8 | 2.7 ± 0.2 × 10−9 |