Figure 1.

Effects of tacrolimus (Tac; µmol·L⁻¹) and cyclosporin (CsA; µmol·L⁻¹) on insulin secretion normalized to insulin content in INS-1E cells. (A) Six hours of incubation at basal (6.6 mmol·L⁻¹) and stimulatory (16.7 mmol·L⁻¹) glucose concentrations. Data are medians with range. n= 6 for controls and n= 3 for each drug concentration. (B) Twenty-four hours of incubation at basal (6.6 mmol·L⁻¹) and stimulatory (16.7 mmol·L⁻¹) glucose concentrations. Data are medians with range. n= 6 for controls and n= 3 for each drug concentration. (C) Twenty-four hours of incubation at basal (3.3 mmol·L⁻¹) and stimulatory (16.7 mmol·L⁻¹) glucose concentrations. Data are medians with range. n= 6 for controls and n= 4 for each drug concentration. *P= 0.01, **P= 0.03 versus control, Kruskal–Wallis test.