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Effects of tacrolimus (Tac; µmol·L−1) and cyclosporin (CsA; µmol·L−1) on apoptosis and necrosis in INS-1E cells. (A) Intracellular DNA fragments (apoptosis) and (B) DNA fragments in medium (necrosis) after 24 h of incubation at basal (6.6 mmol·L−1) and stimulatory (16.7 mmol·L−1) glucose. Data are medians with range. n= 4 for controls and n= 4 for each drug concentration. *P= 0.03, Mann–Whitney U-test.
